Angular cheilitis vitamin b12 deficiency. Feb 13, 2021 · Folate and vitamin B12.

Angular cheilitis vitamin b12 deficiency , vitamin B1, B2, B3, B9 and B12), iron, and protein can increase the chance someone develops angular cheilitis. Elderly people may wear dentures or have sagging skin at the corners of their mouth that contributes to dry mouth corners. The primary cause of Cold Sores is infection with the herpes simplex virus (HSV). Vitamin C helps support immune function and collagen production which aids in wound healing while zinc plays a role in tissue repair and immune system function. [2] In the developing world, iron, vitamin B 12, and other vitamin deficiencies are a common cause. The red beef tongue and burning mouth are more often reported to be related to vita - min B12 deficiency (7). Of the 11 with normal serum vitamin B 12, 9 had received vitamin B 12 before referral but had macrocytosis and low maternal serum Apr 5, 2021 · Vitamin B 1 (thiamine) can be detected by cracked lips or angular cheilitis, 2 a condition that can last for days or years and is detected by “inflammation of one or both corners of the mouth. B12 is a water-soluble vitamin that is involved in red blood cell formation, nervous system function, and DNA synthesis, but your body only gets it through the diet (specifically from animal products) or supplements. Vitamin B12 (cobalamin) is also a crucial cofactor in the synthesis of DNA . Dec 1, 2021 · Angular cheilitis and aphthous stomatitis have also been associated with vitamin B12 deficiency (Brescoll and Daveluy, 2015; Vigarios et al. While seeking medical advice is always recommended, there are some effective home remedies that may help alleviate redness and inflammation associated with angular cheilitis. Additionally, deficiencies of vitamin B (e. Oct 19, 2023 · Can angular cheilitis and sore tongue be caused by a vitamin deficiency? A vitamin deficiency can contribute to the development of angular cheilitis and sore tongue. PMID: 31464357. Pernicious anemia, the most common form of vitamin B12 deficiency, is caused by autoantibodies against intrinsic factor (IF) and/or stomach parietal cells Oct 12, 2023 · Angular cheilitis is a common condition characterized by redness, dryness, and cracking at the corners of the mouth. Pernicious anemia is caused by a vitamin B 12 deficiency. 8 Many other causes can be treated. Overall, however, we were disappointed to discover Another important deficiency associated with angular cheilitis is a lack of Vitamin B3 (Niacin), which can lead to inflammation and irritation of the lips. Vitamin B12 plays a crucial role in maintaining healthy skin and mucous membranes, and its deficiency can lead to the development of angular cheilitis. To address nutritional deficiency-related cheilitis, treatment options include increasing vitamin-rich foods in the diet or taking supplements under medical supervision. Immunosuppressive medications are used to treat SLE but not cheilitis. ) Feb 26, 2024 · Vitamin deficiencies, particularly deficiencies in vitamins B2 (riboflavin), B3 (niacin), B6 (pyridoxine), and B12 (cobalamin), have been linked to the development of angular cheilitis. This condition is commonly caused by a combination of factors such as vitamin deficiencies, fungal or bacterial infections, and irritants like saliva or lip-licking habits. Angular cheilitis and glossitis are mentioned as some of the common symp-toms of iron deficiency (6). 15 In addition to signs/symptoms common to all forms of anemia, other Additionally, nutritional deficiencies such as iron or vitamin B12 deficiency can weaken the immune system and contribute to angular cheilitis development. Jan 6, 2025 · A less common cause of the cracks in the corner of your mouth is a dietary deficiency. Vitamin E: Inadequate intake may contribute to dryness and chapping. Thiamin (B1) b. 2 Jun 13, 2020 · Vitamin B12 deficiency: Spotting these lesions on the corners of the mouth is a warning “Angular cheilitis is inflammation, including redness, swelling, and pain at one or both commissures Mar 7, 2023 · Folate/Vitamin B12 deficiency: Megaloblastic anemia (pernicious anemia) and neurological symptoms. The most common cutaneous manifestation of vitamin B12 deficiency is hyperpigmentation. 2. Angular cheilitis is a fairly common problem, [2] with estimates that it affects 0. Interestingly, studies have shown that up to 50% of people with angular cheilitis have been found to be deficient in vitamin B12. , 2019). One possible cause of the condition is a deficiency in certain nutrients. Deficiencies in B vitamins (B2, B3, B12) or iron can cause dry, cracked lips and redness. Ensure that your diet includes foods rich in these nutrients or consider taking supplements under the guidance of a healthcare professional. Treatment options may include vitamin supplementation , dietary changes , and topical creams or ointments to alleviate symptoms and promote healing. The latter include peripheral neuropathy (paresthesia, ataxia, decreased sensation), cognitive impairment/dementia, and motor deficits (absent reflexes. Vitamin B-2 ( riboflavin) is Apr 14, 2020 · Iron deficiency anemia may cause angular cheilitis, Chapped lips are a common symptom of deficiencies, especially in folate (vitamin B9), riboflavin (vitamin B2), and vitamins B6 and B12 Glossitis was seen in 5 infants and cheilitis in 3. causes angular cheilitis, caused by iron deficiency anaemia, vitamin B12, and folate. Interestingly, I've also got angular cheilitis which has gotten better since I started taking 1. Study with Quizlet and memorize flashcards containing terms like Which B vitamin deficiency is associated with pernicious anemia, glossopyrosis, glossitis, and cheilosis? a. This condition can be caused by a variety of factors, including fungal or bacterial infections, nutritional deficiencies, anemia, and vitamin B12 deficiency. It becomes more frequent with aging. [3] It occurs most often in people in their 30s to 60s, and is also relatively common in children. 5 6 This deficiency is associated with angular cheilitis, glossitis, cognitive symptoms and reduced immunity. Angular cheilitis can be caused not only by trauma but also by systemic conditions such as anemia. Who’s at Risk? Mar 4, 2022 · Vitamin B12 deficiency: Four mouth and lip symptoms warning of low B12 levels in the body Angular cheilitis is another mouth or lips symptom caused by low B12 levels. For example, in the elderly, denture replacement for those without teeth has been found to treat angular cheilitis effectively. Data were used to design a Oct 19, 2023 · The causes of angular cheilitis can be multifactorial and include factors such as fungal or bacterial infections (such as Candida albicans), saliva accumulation due to drooling or lip-licking habits, nutritional deficiencies (such as iron or vitamin B12 deficiency), ill-fitting dentures or braces that cause friction on the skin around the mouth Mar 7, 2023 · Folate/Vitamin B12 deficiency: Megaloblastic anemia (pernicious anemia) and neurological symptoms. Thus, increasing the intake of B2 and eating foods like eggs, milk, and lean meat may help reverse the problem of cheilitis. 1999;58(2):441-8. Epub 2019 Sep 11. vitamin B12, and folate deficiency. This is where the tongue becomes inflamed and sore. “A lack of iron, vitamin B2 (riboflavin), B3 (niacin), vitamin B6, vitamin B12, zinc or folate may cause angular cheilitis,” says Dr. Which B Vitamin B 12 12 deficiency anemia is a macrocytic 13 anemia caused by either inadequate intake of dietary vitamin B 12 (e. 1999;58(2) Angular Cheilitis - An Updated Overview of the Etiology, Diagnosis, and Management Angular cheilitis (AC) is a common clinical entity which Jul 10, 2019 · ปากนกกระจอก (Angular cheilitis) หรือ โรคขาดวิตามิน บี-2 (Vitamin B-2 deficiency) โดย However, when B12 intake is insufficient or absorption is impaired, a deficiency can develop. Nutritional deficiencies account for 25% of all cases of angular cheilitis 3 and include iron deficiency and deficiencies of the B vitamins riboflavin (B 2), niacin (B 3), pyridoxine (B 6), and Oct 13, 2023 · Angular cheilitis, also known as perleche, is a common inflammatory condition characterized by the presence of painful cracks or fissures at the corners of the mouth. deficiency and is characterized by stomatitis, glossitis, and megaloblastic anemia. Vitamin B2 Deficiency. The patient’s complete blood count showed that the Of the 11 with normal serum vitamin B12, 9 had received vitamin B12 before referral but had macrocytosis and low maternal serum vitamin B12. Jan 3, 2023 · A similar study analyzed dermatological signs of vitamin B12 deficiency in infants and found that 6. 0 is grouped within Diagnostic Related Group(s) (MS-DRG v 42. The treatment of angular cheilitis depends on its causes. 5 Low vitamin B6 is associated with renal disease, malabsorption, medication side effects and alcohol use. In the case of zinc, the reason may be poor immune function, as the mineral is vital for wound healing. ” Why does a vitamin B deficiency cause angular cheilitis? “Vitamin B is responsible for tissue repair and Sep 7, 2022 · Nutritional deficiencies account for 25% of all cases of angular cheilitis. However, these two clinical signs may represent other pathology. Diagnosis is made clinica Jan 6, 2025 · Treatment of angular cheilitis: A narrative review and authors' clinical experience. To know Nov 17, 2022 · Angular cheilitis is inflammation of the angles of the mouth, characterised by fissures, scaling, erythema, and crusting. This condition is specifically known as ‌angular cheilitis (‌also called ‌angular cheilosis, angular stomatitis‌ or ‌perlèche),‌ and is essentially an inflammation of the lips. These habits and products keep the tissues wet and allow development of candidiasis. Are you saying that I should up my methylfolate dose? Oct 12, 2023 · In addition to vitamin B2, other vitamins such as vitamin C and zinc may also be beneficial for individuals with angular cheilitis. 5mg folate/b12/ b complex a month ago but it still causes issues. We aimed to develop a widely accepted expert consensus to guide the practice of diagnosing and treating B12 deficiency. The effects of iron deficiency are similar to those of the vitamin B deficiency. "If the cracks are accompanied by a sore tongue it’s a less common sign of a vitamin B deficiency. Folate deficiency often presents with vitamin B. Oct 19, 2023 · By: Medical Review Team October 19, 2023; Table of Contents Oct 19, 2023 · Causes of Angular Cheilitis. Apr 10, 2024 · Background/Objectives: Vitamin B12 deficiency can cause variable symptoms, which may be irreversible if not diagnosed and treated in a timely manner. A person with a vitamin and possible mineral deficiency can benefit from loblastic anemias are cobalamin (vitamin B 12) and folate (vitamin B 9) deficiency. Feb 13, 2021 · Folate and vitamin B12. g. Riboflavin (B2) c. Vitamin B2, B3, B6, or B12 deficiency. There are other studies linking cheilitis to vitamin B12 deficiency and pernicious anemia (Shanghai Journal of Stomatology, June, 2022; Journal of Oral Pathology & Medicine, Nov. HSV exists in two forms: HSV-1 and HSV-2. There are four signs in your mouth and lips that could suggest you have a vitamin B12 deficiency. This is because vitamin B12 is mainly found in animal product foods such as meat, eggs and cheese and is therefore frequent among vegetarians and Angular cheilitis isn’t always caused by an infection or iron/b12 deficiency. especially in the vitamin B group; If your doctor determines that angular cheilitis is the result of a nutritional deficiency Jan 23, 2024 · The condition is also more likely to occur in individuals with poor health, such as those with coeliac disease, zinc deficiency, or vitamin B12 and/or folate deficiency. These vitamins play essential roles in maintaining healthy skin, promoting wound healing, and supporting the immune system. if a person’s immune system is not working effectively because of diabetes or drugs used in chemotherapy to treat cancer) Cheilitis may also be associated with numerous conditions or diseases, e. Cobalamin (B12), A patient presents with burning, itchy eyes, loss of visual acuity, dermatitis, glossitis, and angular cheilosis. Differential diagnosis plays a crucial role in distinguishing angular cheilitis from other conditions that present similar symptoms. [5] Sep 7, 2022 · Pernicious anemia is caused by a vitamin B 12 deficiency. Regular monitoring of nutrient levels is Angular cheilitis tends to be most common in the very old and very young. A riboflavin deficiency can also cause angular cheilitis. Jun 24, 2024 · Angular cheilitis causes pain and inflammation in the corners of the mouth. On the other hand, hemolytic anaemia is rarely reported as a cause of angular cheilitis. People predisposed to angular cheilitis may also have: Iron deficiency. Jun 29, 2022 · Other risk factors for angular cheilitis include those with chronic health conditions, such as diabetes or inflammatory bowel disease (IBD). 19 Angular cheilitis is also seen in younger dentate patients who are HIV positive, most likely as a result of decreased immunity. While often attributed to environmental factors or infections, a deficiency in riboflavin (Vitamin B2 Vitamin B12: Deficiency may manifest as swollen or pale lips. Oct 12, 2023 · Can angular cheilitis be caused by a vitamin deficiency? Yes, angular cheilitis can be caused by a vitamin deficiency. Which B This fungus, responsible for conditions like diaper rash in babies, can thrive in the moist environment around the mouth, leading to irritation, redness, and the characteristic soreness of Angular Cheilitis. angular cheilitis and oral candidiasis (4, 5). Biotin (B7) f. htt- such as vitamin B or iron deficiency. Pacifiers, thumb-sucking and drooling can irritate infants’ mouths. 07% of participants presented with angular cheilitis. 13183. Poor nutrition — coeliac disease, iron deficiency, riboflavin deficiency, general protein deficiency, zinc deficiency, vitamin B12 and/or folate deficiency; Systemic illness, particularly inflammatory bowel disease (ulcerative colitis and Crohn disease) and Sjogren syndrome; Sensitive skin, especially atopic dermatitis Oct 12, 2023 · Angular cheilitis, characterized by these symptoms, is often caused by a deficiency in vitamin B12. Angular cheilitis can occur when there is inadequate intake or absorption of essential vitamins and minerals, such as iron, zinc, riboflavin (), and vitamin B12. The Angular Cheilitis Institute is able to support our heavy operating, research, & development costs thanks to these commissions. The infants were treated with vitamin B12. Of the 32 infants who underwent laboratory investigations, 28 had anemia and 21 macrocytosis. The patient’s complete blood count showed that the Study with Quizlet and memorize flashcards containing terms like Which B vitamin deficiency is associated with pernicious anemia, glossopyrosis, glossitis, and cheilosis? a. 1-3 Clinically, megaloblastic anemia progresses slowly, and symptoms include weakness, fa-tigue, shortness of breath and neurologic abnormalities. 1995). Mar 16, 2023 · A deficiency in riboflavin (vitamin B2) may also lead to angular cheilitis. The disease has a mixed etiology, mostly with bacterial and fungal components. Vitamin B2 (Riboflavin) Deficiency Oct 12, 2023 · Angular Cheilitis Vitamin B12 Deficiency Medical Review Team October 12, Angular Cheilitis Vitamin D Deficiency Medical Review Team October 12, 2023 Feb 3, 2020 · Dr Scurr said: ”Experiencing angular cheilitis could be due to a vitamin B12 deficiency. Vitamin B12 Deficiency of vitamin B6 rarely occurs in isolation and is often identified with other B vitamin deficiencies. Aetiology is multi-factorial and includes mechanical factors, infectious agents, nutritional deficiencies, or inflammatory dermatological conditions. Serum vitamin B 12 was measured in 30 infants; it was low in 19. 12. Folate deficiency. A special type is angular cheilitis. For example, a lack of vitamin B12 can cause angular cheilitis, known as glossitis and Oxnard’s tendinitis. In the case of angular cheilitis associated with pernicious anemia (itself due to a form of vitamin B-12 deficiency), oral manifestations include mucosal pallor; atrophic, painful mucosa, and reddened mucosa; mucosal ulceration; loss of papillae on the dorsum of the tongue; and burning and painful tongue. Jun 28, 2024 · Like B vitamins and iron, a zinc deficiency can cause angular cheilitis. Causes of Vitamin B12 Deficiency. It has two age peaks: one during childhood and another in adults. , nutritional deficiencies, such as megaloblastic anemia due to vitamin B 12 deficiency, anemia due to iron deficiency, oral candidiasis, diabetes (2, 4-8). While there can be multiple underlying causes for this condition, one potential factor that has been identified is a deficiency in vitamin B2 (riboflavin). Vitamin B12 deficiency can develop due to two main reasons: insufficient intake and malabsorption. Mar 22, 2024 · Cheilitis is a common inflammatory disorder of the vermillion and adjacent skin of the lips. In one study, it was shown that iron-replacement therapy for patients suffering from iron-deficiency anemia caused significant regression of angular cheilitis. 3% of patients with angular cheilitis suffered from iron deficiency anaemia [5]. Mar 7, 2023 · Folate/Vitamin B12 deficiency: Megaloblastic anemia (pernicious anemia) and neurological symptoms. Specifically, deficiencies in vitamins B2 (riboflavin), B3 (niacin), and B12 (cobalamin) have been associated with the development of angular cheilitis. doi: 10. 1111/odi. Mar 13, 2019 · Awareness that angular cheilitis may be associated with nutritional deficiency (B2, B12, folate, iron, zinc), vitamin overdose (hypervitaminosis A), anemia of chronic disease, or undiagnosed immunosuppressing systemic disorders (HIV, DM, primary immunodeficiency) will enable the physician to perform appropriate testing to diagnose any loblastic anemias are cobalamin (vitamin B 12) and folate (vitamin B 9) deficiency. Rambhia, who emphasizes that a nutritional deficiency is a relatively rare catalyst for the condition. “It can also be a sign of vitamin B deficiency. Clinical Mar 5, 2022 · Vitamin B12 deficiency: Four mouth and lip symptoms that suggest low B12 levels. Oct 12, 2023 · By addressing this angular cheilitis vitamin deficiency and ensuring an adequate intake of vitamin B, individuals with angular cheilitis can effectively treat their condition. Methods: We conducted a scoping review of the literature published in PubMed since January 2003. 6 There is also an introduction: Angular cheilitis is a lesion in the corner of the lips caused by many factors, including nutritional deficiencies and systemic diseases. This may be due to the deficiency in vitamins B 2, B 3, B 6, and B 12. 20 Aug 1, 2018 · A wide variety of factors, including nutritional deficiencies, local and systemic factors, and drug side effects, may produce cheilitis. Cheilocandidiasis may exist in patients prone to oral habits such as lip-licking and chronic use of petrolatum-based salves and lip balms. ICD-10-CM E53. ” 5 Also, vitamin B 2 (riboflavin) and vitamin B 3 deficiency can cause inflammation of the tongue, angular cheilitis, and ulcerative gingivitis. How to Differentiate Vitamin Deficiency from Cheilitis Feb 14, 2021 · Folate and vitamin B12. Recent studies carried out in patients with cheilitis, analyzing Dec 18, 2024 · Angular cheilitis usually appears at the corners of the mouth. Folate supplementation is affected by methotrexate, phenytoin, phenobarbital, primidone, oral contraceptives, and triamterene. The body requires iron, vitamin B-12 and folic acid to produce healthy red blood cells within the bone marrow. Another potential cause of Angular Cheilitis is a deficiency in riboflavin, also known as vitamin B2. ) Lack of vitamin B12 can also cause glossitis and angular cheilitis. A deficiency of vitamin B-12 or folic acid results in immature red blood cells and a condition called pernicious anaemia. The causes of Angular cheilitis are multifactorial of local and systemic etiology. The most common sign of vitamin B12 deficiency on the skin, observed in almost all patients, was cutaneous hyperpigmentation . Inclusion criteria were: (1) studies that explicitly explore the relationship between vitamin deficiencies and oral health issues in children, including research on oral symptoms (such as enamel defects, cheilitis, glossitis, and gingivitis) attributable to vitamin insufficiency; (2) articles providing statistical analyses of the prevalence Feb 26, 2024 · Address Nutritional Deficiencies: Angular cheilitis can be associated with nutritional deficiencies, particularly deficiencies in iron, vitamin B12, and zinc. Pyridoxine (B6) e. Vitamin B12 deficiency can lead to a variety of health problems, ranging from fatigue and anemia to neurological issues. Vitamin deficiency is the most common cause of cheilitis. 7% of the population. Oral signs and symptoms, in-cluding glossitis, angular cheilitis, recurrent Oct 20, 2023 · Common laboratory tests include blood tests to check for iron deficiency anemia or vitamin B12 deficiency, as well as swabs or cultures from the affected area to detect bacterial or fungal infections. Vitamin B 12 12 deficiency anemia is a macrocytic 13 anemia caused by either inadequate intake of dietary vitamin B 12 (e. The latter include peripheral neuropathy (paresthesia, ataxia, decreased sensation), cognitive impairment/dementia, motor deficits (absent reflexes. Angular cheilitis may be a clinical sign of an underlying disease. All these vitamins are essential to human health, but a deficiency can lead to angular cheilitis. , in long-standing strict veganism or vegetarianism 14 without vitamin supplementation) or by malabsorption/poor processing of vitamin B 12. Sep 20, 2023 · Angular cheilitis is also seen in the setting of iron; vitamin B2, B3, B6, or B12; zinc; and folate deficiency, although these represent a much less common cause of angular cheilitis. This condition shows up as cracks or sores at the corners of the mouth and can affect Nov 30, 2016 · 8, 11 Malnutrition is a cause of angular cheilitis. Oral Dis. Vitamin B12 deficiency (Crohn disease as absorbed from small bowel) – glossitis (beefy red tongue with flat red patches mainly on the sides and top of the tongue), angular cheilitis, mouth ulcers, oral candidiasis, diffuse erythematous mucositis, pale oral mucosa, soreness of the tongue or mouth, burning mouth, reduced taste sensitivity Condition due to a deficiency of riboflavin (vitamin b12) which is associated with inadequate consumption of riboflavin rich foods; produces lesions of skin, digestive tract and nervous system; usually part of a multiple nutrient deficiency. Niacin (B3) d. If your doctor can’t find the cause, it’s called idiopathic angular cheilitis. Jun 17, 2024 · Chronic pooling of saliva encourages fungal and bacterial growth, and people who wear dentures, are immunocompromised, have undergone head and neck radiation, or have diabetes are prone to developing angular cheilitis. 0): Less common contributing factors for the development of angular cheilitis include nutritional deficiencies such as iron, vitamin B 12, folic acid, thiamine, and riboflavin. See full list on dermnetnz. org Oct 12, 2023 · Angular cheilitis, characterized by these symptoms, is often caused by a deficiency in vitamin B12. Angular cheilitis - An updated overview of the etiology, diagnosis, and management. A deficiency in vitamins B1, B2, B3 and B12 is known to cause cracks in the corners of the mouth. 2 Jul 1, 2011 · Oral mucosal changes including cheilitis lesions represent a cardinal symptom of vitamin B12 deficiency and may represent the earliest clinical sign of B12 deficiency, as in our patient. Lack of vitamin B-2 (riboflavin), vitamin B-3 (niacin), vitamin B-6 (pyridoxine), or vitamin B-12 (cyanocobalamin) and iron deficiency can cause Dec 7, 2021 · B12 deficiency: The ‘corner of the mouth’ warning that shows your vitamin levels are low. It might be as simple as having used an active ingredient around the mouth area, combined with increasingly cold/dry air as we approach winter. Additionally, cheilitis is often divided into particular subtypes with no clear classification having yet been Megaloblastic anemias are a subgroup of macrocytic anemias, in which distinctive morphologic abnormalities occur in red cell precursors in bone marrow, namely megaloblastic erythropoiesis. Chronic alcoholism, tropical and celiac sprues, Oct 12, 2023 · The symptoms of angular cheilitis typically include redness, swelling, and cracking at the corners of the mouth, accompanied by pain or discomfort. Jan 17, 2023 · The authors mention angular cheilitis and other nutritional deficiencies of vitamin B12: iron and folic acid. The absence of vitamin B2 in the body slows down the metabolism of fats, proteins, and carbohydrates and decreases energy production. A study showed that only 35. 2020 Sep;26(6):1107-1115. Vitamin Deficiency. B12 is an essential vitamin which is found in meat, fish, eggs and dairy products. Jan 12, 2023 · “People often confuse angular cheilitis with cold sores. Folate/Vitamin B12 deficiency: Megaloblastic anemia (pernicious anemia) and neurological symptoms. Jan 2, 2025 · Though not directly a symptom of nail deficiency, angular cheilitis often accompanies Vitamin B12 deficiency. Angular cheilitis is reported to be more common in individuals with inflammatory bowel disease ( Crohn disease and ulcerative colitis ), orofacial granulomatosis According to our experience and clinical practice, we suggest classification based on primary differences in the duration and etiology of individual groups of cheilitis, as follows: 1) mainly reversible (simplex, angular/infective, contact/eczematous, exfoliative, drug-related); 2) mainly irreversible (actinic, granulomatous, glandular, plasma Cracks at the corners of the mouth, known as angular cheilitis, can be painful and persistent. Oral signs and symptoms, in-cluding glossitis, angular cheilitis, recurrent Jan 12, 2023 · A common vitamin B deficiency is vitamin B12. “Unlike cold sores, angular cheilitis isn’t contagious. Krishnan PAnitha, Anil S, Vijayan SP. 1,2. “This condition usually goes away with antifungal skin ointments. Oct 12, 2023 · Angular Cheilitis Vitamin B12 Deficiency This website uses affiliate links which may earn us a commission for certain purchases made by our readers, at no additional cost to them. These deficiencies may also lead to symptoms such as fatigue, weakness, or a swollen tongue. There is a correlation between oral lichen planus occurrence and iron, folic acid, and vitamin B12 deficiency . Mar 7, 2023 · Folate/Vitamin B12 deficiency: Megaloblastic anemia (pernicious anemia) and neurological symptoms. Additionally, deficiencies in iron, zinc, and Vitamin B12 have also been implicated in the development of angular cheilitis. Of the many causes of megaloblastic anemia, the most common are disorders resulting from cobalamin or folate de … Dec 6, 2024 · Specifically, having a vitamin B12 deficiency, iron deficiency, and a lack of protein can lead to angular cheilitis. • Nutritional deficiency including riboflavin, iron, vitamin B12 and zinc • A compromised immune system (e. 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